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Takata Y, Cai Q, Beeghly-Fadiel A, et al. Sex am B vitamin and methionine intakes and lung cancer risk among female never sex am in China.

Bassett JK, Hodge AM, English DR, et al. Dietary intake of B vitamins and methionine and risk of lung sex am. Ebbing M, Bonaa KH, Nygard O, et al. Cancer incidence and mortality after treatment with folic acid and vitamin B12. Tsao S-M, Yin M-C, Liu W-H. Oxidant stress and B vitamins status in patients sex am non-small cell lung cancer.

Aagaard L, Strandell J, Melskens L, Sex am PS, Holme Hansen E. Coronaviruses and influenza are among the viruses that can cause lethal lung injuries and death from acute respiratory distress syndrome worldwide (1). Currently, there is no registered treatment or vaccine for COVID-19, and an alternative solution to protect against COVID-19 is urgently needed.

Vitamin B6 is a water-soluble vitamin found in sex am foods such as fish, whole grains, and banana (10). There are six isoforms of B6 vitamers (10). There is growing evidence that vitamin B6 exerts a protective effect against chronic diseases sex am as cardiovascular diseases (CVD) and diabetes by suppressing inflammation, inflammasomes, oxidative stress, and carbonyl stress (11).

In view of these information, we postulated potential role of vitamin B6 in ameliorating the severity of COVID-19 and its complications (Figure 1).

In this swx, we review precedent research to test this hypothesis. Sex am protective role of vitamin B6 in ameliorating the severity of COVID-19 and its complications such as hypertension, cardiovascular diseases and sex am complications. Besides these comorbidities, high cumulative incidence of thrombotic sex am was found in critically ill patients with COVID-19 pneumonia in Dutch hospitals (15).

Thus, these groups and patients with chronic diseases are more likely to require critical care. COVID-19 is caused by SARS-CoV2. The virus mainly enters the body by binding sex am the angiotensin converting enzyme (ACE) 2 receptor, which is читать больше expressed in lung alveolar cells and epithelial cells in the respiratory tract, thus causing lung injury (1).

Besides cells in the airways, the ACE2 receptor is highly expressed in cardiac and vascular endothelial cells sex am, 2), which potentially make heart and blood vessels target organs for the virus. This may explain common cardiovascular complications with poor sex am in COVID-19 patients an CVD and hypertension.

Since blood vessels traverse multiple organs, this may partly explain sex am inflammation and multi-organ failure, commonly found in COVID-19 patients. Another feature of COVID-19 is cytokine storm, wex from opiate dependence and aberrant host immune responses (1, 3).

Studies of COVID-19 patients' serum show lymphopenia and a marked increase in inflammatory markers such as interleukin-6 (IL-6) and C-reactive protein (CRP). Thus, it can be hypothesized that for chronic inflammatory diseases such as diabetes where the immune response is impaired, abnormal immune activation and hyperinflammation in COVID-19 possibly make patients more susceptible to viral infection. In this sex am, we will analyze this problem in terms of nutrition.

The rationale for using sex am B6 as a possible adjuvant sexx for COVID-19 is discussed in se following sections. Evidence suggests sex am a low dietary intake of vitamin B6 is associated with a high risk of mortality risk from CVD, and vitamin B6 supplementation reduces this risk (11, 16). In humans, low PLP plasma levels are associated with a high risk of A, atherosclerosis, stroke, and thrombosis (11, 16).

Recently, the sex am of vitamin B6 in CVD risk has been addressed through chronic inflammation, a crucial mechanism underlying atherosclerosis and CVD progression. Plasma PLP levels sex am inversely correlated with systemic нажмите для продолжения markers such as CRP (17).

Vitamin B6 supplementation suppressed IL-6 and increased total lymphocytes in patients with chronic conditions (18). Recently, novel heart protective effects of vitamin B6 have been proposed such as regulating homeostasis of imidazole dipeptides, e. In line with this, vitamin B6 supplementation showed blood pressure lowering effect in hypertensive patients (21). Additionally, oral administration of vitamin B6 attenuates platelet aggregation and clot formation (22).



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21.06.2020 in 19:13 Викентий:
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23.06.2020 in 15:06 Леон:

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